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KMID : 0362719830210060473
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Journal of the Korean Dental Association
1983 Volume.21 No. 6 p.473 ~ p.483
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EFFECT OF CADMIUM ON THE MINERAL COMPOSITION IN THE SERUM, TIBIA AND TEETH OF ALBINO RAT
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Abstract
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Cadmium is ubiquitous metal that has come to be recognized as a highly toxic metal and once obsorbed. Cadmium is very efficiency retained in the body..
This experiment was undertaken to determine
1. The effects of several levels of cadmium on growth and feed efficiency of rats.
2. The effects of cadmium on some minerals concentration in the serum, tibia and teeth.
Fifty-five males of Spraque-Dewley strain, 100 + 5g were divided into 5 groups and each w group (1l rats) was fed ad libitum for 4 weeks.
Control group received distilled drinking water, other groups were givin water containing cadmium at the levels of 5, 10, 20, 40 ppm.
These solutions were prepared by diluting a stock solutionof cadmium chloride´ with distilled water. - ine results ontamea are summarized as tollow.
Growth rate was significantly decreased as the feeding level of cadmium increased, expecially body weight in the 40ppm level was greatly reduced than that of initial body weight. The weight of liver wasincreased in 40 ppm group as a result of edema. But, the weight of kidney, heart, spleen, lung and testis was not affected.
The cadmium concentration of sermrm was higher in rats receiving 40 ppm than that of other levels, and the concentrations of iron, zinc, copper, magnesium and calcium were decreased
as the cadmium content of drinking water increased.
a
The cadmium and phosphorus contents of tibia were greatly high in the 40 ppm level, but
the content of iron, copper, zinc, magnesium, calium and ash tended to be decreased with increasing level of cadmium.
A
The cadmium concentration of teeth was predominantly high compared with that of the serum and tibia. Particulary, the cadmium concentration in the 40 ppm level has as much as three, or twenty folds with compared to other treatments. Also, the concentration of iron, copper and zinc tended to be decreased with increasing cadmium level, but the contents of magnesium, cal: ciurn and ash tended to be increased.
Despite high- incidences of dental caries and periodontal diseases among the Korean school´ children, few socially significant policy measures have been taken for improvement of school dental health program.
This study was conducted to identify present status of school dental health program based upon relevant data available for more efficient school dental health program.
The results are summarized as follows:
1. Administrative organization reform is urgently called for by newly establishing;´ 1) A School Health Committee at the level of both Municipal/Provincial Board´ of Education and Town-ship Office of EdVcation, 2) Bureau of School Health Service and Section of School Dental Health Service within the arms of Ministry of Education, 3) Dental Affairs Division in the Bureau of Medical Affairs, Ministry of Health and Social Affairs, and 4) School Health Service Clinic in Pusan and every Province.
2. Dental health resources should be more efficiently utilized and strengthened by newly institutionalizing; 1) Use of dental hygienists for school dental health program as early as possible, 2) A commissioning dentist system for several school with a community under the responsible
´ authorities, and 3) Production of dental hygienivs at the College of Dentistry.
3. The following activities are recommended to strengthen the existing school dental health program; 1) Inclusion of appropriate dental health curricula for elementary school, 2) Development of mobile school dental health education program and person-to-person dental guidance; program by using dental hygienists, 3) Implementing _water fluoridation program in urban area and topical application of fluoride (mouth rinsing method) in rural area, and 4) Periodical dental check up for school children.
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